Adult-Onset Still’s Disease : From Pathophysiology to Targeted Therapies
Joint Authors
Spyridakis, Evangelos G.
Koutsilieris, Michael
Mavragani, Clio P.
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder affecting primarily young individuals.
The diagnosis is primarily clinical and necessitates the exclusion of a wide range of mimicking disorders.
Given the lack of solid data in regard to the underlying pathogenetic mechanisms, treatment of AOSD has been for years largely empirical.
Recent advances have revealed a pivotal role of several proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-18 (IL-18) in disease pathogenesis, giving rise to the development of new targeted therapies aiming at optimal disease control.
American Psychological Association (APA)
Mavragani, Clio P.& Spyridakis, Evangelos G.& Koutsilieris, Michael. 2012. Adult-Onset Still’s Disease : From Pathophysiology to Targeted Therapies. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-505603
Modern Language Association (MLA)
Mavragani, Clio P.…[et al.]. Adult-Onset Still’s Disease : From Pathophysiology to Targeted Therapies. International Journal of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-505603
American Medical Association (AMA)
Mavragani, Clio P.& Spyridakis, Evangelos G.& Koutsilieris, Michael. Adult-Onset Still’s Disease : From Pathophysiology to Targeted Therapies. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-505603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505603
