Antiproliferative Activity of Hamigerone and Radicinol Isolated from Bipolaris papendorfii
Joint Authors
Deshmukh, Sunil Kumar
Gohil, Akash R.
Verekar, Shilpa A.
Giridharan, Periyasamy
Mishra, Prabhu Dutt
Khanna, Amit
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Secondary metabolites from fungi organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification.
Through high throughput screening (HTS) and bioassay-guided isolation, we isolated two bioactive compounds hamigerone (1) and radicinol (2).
These compounds were isolated from fungus Bipolaris papendorfii, isolated from the rice fields of Dera, Himachal Pradesh, India.
The structures of the compounds were established on the basis of spectroscopic data, namely, NMR (1H, 13C, mass, and UV).
Both compounds were found to be antiproliferative against different cancer cells.
Furthermore we have also noted that both compounds showed increase in apoptosis by favorably modulating both tumor suppressor protein (p53) and antiapoptic protein (BCL-2), and in turn increase caspase-3 expression in cancer cells.
This is the first report of these compounds from fungus Bipolaris papendorfii and their anticancer activity.
American Psychological Association (APA)
Giridharan, Periyasamy& Verekar, Shilpa A.& Gohil, Akash R.& Mishra, Prabhu Dutt& Khanna, Amit& Deshmukh, Sunil Kumar. 2014. Antiproliferative Activity of Hamigerone and Radicinol Isolated from Bipolaris papendorfii. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505778
Modern Language Association (MLA)
Giridharan, Periyasamy…[et al.]. Antiproliferative Activity of Hamigerone and Radicinol Isolated from Bipolaris papendorfii. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-505778
American Medical Association (AMA)
Giridharan, Periyasamy& Verekar, Shilpa A.& Gohil, Akash R.& Mishra, Prabhu Dutt& Khanna, Amit& Deshmukh, Sunil Kumar. Antiproliferative Activity of Hamigerone and Radicinol Isolated from Bipolaris papendorfii. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-505778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505778