Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)
Joint Authors
Kumar, M. Saravana
Das, S. Mohan
Devi, P. Suganya
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Breast cancer is a leading cause of death in women worldwide both in the developed and developing countries.
Thus effective treatment of breast cancer with potential antitumour drugs is important.
In this paper, human breast cancer cell line MCF-7 has been employed to evaluate the antiproliferative activity of red sorghum bran anthocyanin.
The present investigation showed that red sorghum bran anthocyanin induced growth inhibition of MCF-7 cells at significant level.
The growth inhibition is dose dependent and irreversible in nature.
When MCF-7 cells were treated with red sorghum bran anthocyanins due to activity of anthocyanin morphological changes were observed.
The morphological changes were identified through the formation of apoptopic bodies.
The fragmentation by these anthocyanins on DNA to oligonuleosomal-sized fragments, is a characteristic of apoptosis, and it was observed as concentration-dependent.
Thus, this paper clearly demonstrates that human breast cancer cell MCF-7 is highly responsive by red sorghum bran anthocyanins result from the induction of apoptosis in MCF-7 cells.
American Psychological Association (APA)
Devi, P. Suganya& Kumar, M. Saravana& Das, S. Mohan. 2011. Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7). International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-505842
Modern Language Association (MLA)
Devi, P. Suganya…[et al.]. Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7). International Journal of Breast Cancer No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-505842
American Medical Association (AMA)
Devi, P. Suganya& Kumar, M. Saravana& Das, S. Mohan. Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7). International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-505842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505842