Prevalence of Catalase (-21 AT) Gene Variant in South Indian (Tamil) Population
Joint Authors
Angeline, T.
Lourdhu Mary, A.
Nithya, K.
Isabel, W.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Catalase, an endogenous antioxidant enzyme, is responsible for regulating reactive species levels.
Several epidemiologic studies have suggested that single nucleotide polymorphism in catalase gene may be associated with many diseases.
The genotype of CAT (-21 A/T) point mutation in promoter region of catalase gene was determined by polymerase chain based restriction fragment length polymorphism analysis in the DNA of 100 healthy volunteers.
The frequency of CAT (-21 A/T) gene polymorphism AA, AT, and TT genotypes was found to be 7, 23, and 70 percent, respectively.
The mutant “T” allele frequency was found to be 0.82 among the south Indian (Tamil) population.
Chi square analysis showed that the study population lies within the Hardy-Weinberg equilibrium.
The wild type genotype (AA) was found to be very low (7%) and the mutant genotype (AT/TT) was found to be more prevalent (93%) among the south Indian population.
This suggests that the high prevalence of mutant genotype may increase the susceptibility to oxidative stress associated diseases.
American Psychological Association (APA)
Lourdhu Mary, A.& Nithya, K.& Isabel, W.& Angeline, T.. 2014. Prevalence of Catalase (-21 AT) Gene Variant in South Indian (Tamil) Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-506093
Modern Language Association (MLA)
Lourdhu Mary, A.…[et al.]. Prevalence of Catalase (-21 AT) Gene Variant in South Indian (Tamil) Population. BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-506093
American Medical Association (AMA)
Lourdhu Mary, A.& Nithya, K.& Isabel, W.& Angeline, T.. Prevalence of Catalase (-21 AT) Gene Variant in South Indian (Tamil) Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-506093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506093