Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms
Joint Authors
Aschner, Michael
Martinez-Finley, Ebany J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Metals have been definitively linked to a number of disease states.
Due to the widespread existence of metals in our environment from both natural and anthropogenic sources, understanding the mechanisms of their cellular detoxification is of upmost importance.
Organisms have evolved cellular detoxification systems including glutathione, metallothioneins, pumps and transporters, and heat shock proteins to regulate intracellular metal levels.
The model organism, Caenorhabditis elegans (C.
elegans), contains these systems and provides several advantages for deciphering the mechanisms of metal detoxification.
This review provides a brief summary of contemporary literature on the various mechanisms involved in the cellular detoxification of metals, specifically, antimony, arsenic, cadmium, copper, manganese, mercury, and depleted uranium using the C.
elegans model system for investigation and analysis.
American Psychological Association (APA)
Martinez-Finley, Ebany J.& Aschner, Michael. 2011. Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506178
Modern Language Association (MLA)
Martinez-Finley, Ebany J.& Aschner, Michael. Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms. Journal of Toxicology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506178
American Medical Association (AMA)
Martinez-Finley, Ebany J.& Aschner, Michael. Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506178