Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation
Joint Authors
Woźniak, Alina
Szpinda, Michał
Mila-Kierzenkowska, Celestyna
Woźniak, Bartosz
Górecki, Dariusz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The effect of smoking cessation on the oxidative stress in patients with chronic obstructive pulmonary disease (COPD) was assessed.
We recruited 73 smokers with COPD (study group), whose blood was analysed before smoking cessation, after the 1st, 2nd, and 3rd months of abstinence, 35 healthy nonsmokers (Control I), and 35 smokers with COPD (Control II).
Blood was taken once in Control I and 4 times (every month) in Control II.
In the study group conjugated dienes (CDs) level in plasma and erythrocytes before smoking cessation was 3 and 6.5 times higher than in Control I, respectively (P<0.001), while thiobarbituric acid-reactive substances (TBARS) level was 89% (P<0.001) and 51% higher (P<0.01), respectively.
Superoxide dismutase (SOD) activity was 40% higher (P<0.05) while glutathione peroxidase (GPx) was 41% lower (P<0.001) than in Control I.
In Control II, the similar differences as compared to Control I were observed throughout the study.
Smoking cessation resulted in decrease of CDs, TBARS, and SOD and GPx increase, with no changes in catalase and vitamins A and E.
COPD is accompanied by oxidative stress.
A three-month tobacco abstinence facilitated restoring the oxidant-antioxidant balance systemically, but it did not affect spirometric parameters.
American Psychological Association (APA)
Woźniak, Alina& Górecki, Dariusz& Szpinda, Michał& Mila-Kierzenkowska, Celestyna& Woźniak, Bartosz. 2013. Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-506342
Modern Language Association (MLA)
Woźniak, Alina…[et al.]. Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-506342
American Medical Association (AMA)
Woźniak, Alina& Górecki, Dariusz& Szpinda, Michał& Mila-Kierzenkowska, Celestyna& Woźniak, Bartosz. Oxidant-Antioxidant Balance in the Blood of Patients with Chronic Obstructive Pulmonary Disease After Smoking Cessation. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-506342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506342