Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells
Joint Authors
Kaneko, Naoko
Sawamoto, Kazunobu
Nakaguchi, Kanako
Masuda, Hiroshi
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Currently, there is no effective treatment for the marked neuronal loss caused by neurodegenerative diseases, such as Huntington's disease (HD) or ischemic stroke.
However, recent studies have shown that new neurons are continuously generated by endogenous neural stem cells in the subventricular zone (SVZ) of the adult mammalian brain, including the human brain.
Because some of these new neurons migrate to the injured striatum and differentiate into mature neurons, such new neurons may be able to replace degenerated neurons and improve or repair neurological deficits.
To establish a neuroregenerative therapy using this endogenous system, endogenous regulatory mechanisms that can be co-opted for efficient regenerative interventions must be understood, along with any potential drawbacks.
Here, we review current knowledge on the generation of new neurons in the adult brain and discuss their potential for use in replacing striatal neurons lost to neurodegenerative diseases, including HD, and to ischemic stroke.
American Psychological Association (APA)
Nakaguchi, Kanako& Masuda, Hiroshi& Kaneko, Naoko& Sawamoto, Kazunobu. 2011. Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells. Neurology Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506427
Modern Language Association (MLA)
Nakaguchi, Kanako…[et al.]. Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells. Neurology Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506427
American Medical Association (AMA)
Nakaguchi, Kanako& Masuda, Hiroshi& Kaneko, Naoko& Sawamoto, Kazunobu. Strategies for Regenerating Striatal Neurons in the Adult Brain by Using Endogenous Neural Stem Cells. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506427