Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory
Joint Authors
Kamimura, Daisuke
Arima, Yasunobu
Ogura, Hideki
Yamada, Moe
Sabharwal, Lavannya
Atsumi, Toru
Bando, Hidenori
Murakami, Masaaki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The central nervous system (CNS) is an immune-privileged environment protected by the blood-brain barrier (BBB), which consists of specific endothelial cells that are brought together by tight junctions and tight liner sheets formed by pericytes and astrocytic end-feet.
Despite the BBB, various immune and tumor cells can infiltrate the CNS parenchyma, as seen in several autoimmune diseases like multiple sclerosis (MS), cancer metastasis, and virus infections.
Aside from a mechanical disruption of the BBB like trauma, how and where these cells enter and accumulate in the CNS from the blood is a matter of debate.
Recently, using experimental autoimmune encephalomyelitis (EAE), an animal model of MS, we found a “gateway” at the fifth lumber cord where pathogenic autoreactive CD4+ T cells can cross the BBB.
Interestingly, this gateway is regulated by regional neural stimulations that can be mechanistically explained by the gate theory.
In this review, we also discuss this theory and its potential for treating human diseases.
American Psychological Association (APA)
Arima, Yasunobu& Kamimura, Daisuke& Sabharwal, Lavannya& Yamada, Moe& Bando, Hidenori& Ogura, Hideki…[et al.]. 2013. Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506446
Modern Language Association (MLA)
Arima, Yasunobu…[et al.]. Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506446
American Medical Association (AMA)
Arima, Yasunobu& Kamimura, Daisuke& Sabharwal, Lavannya& Yamada, Moe& Bando, Hidenori& Ogura, Hideki…[et al.]. Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506446