Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor
Joint Authors
Anose, Bynthia M.
Sanders, Michel M.
Source
International Journal of Endocrinology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The zinc finger E-box binding protein 1 (ZEB1) transcription factor belongs to a two-member family of zinc-finger homeodomain proteins involved in physiological and pathological events mostly relating to cell migration and epithelial to mesenchymal transitions (EMTs).
ZEB1 (also known as δEF1, zfhx1a, TCF8, and Zfhep) plays a key role in regulating such diverse processes as T-cell development, skeletal patterning, reproduction, and cancer cell metastasis.
However, the factors that regulate its expression and consequently the signaling pathways in which ZEB1 participates are poorly defined.
Because it is induced by estrogen and progesterone and is high in prostate cancer, we investigated whether tcf8, which encodes ZEB1, is regulated by androgen.
Data herein demonstrate that tcf8 is induced by dihydrotestosterone (DHT) in the human PC-3/AR prostate cancer cell line and that this induction is mediated by two androgen response elements (AREs).
These results demonstrate that ZEB1 is an intermediary in androgen signaling pathways.
American Psychological Association (APA)
Anose, Bynthia M.& Sanders, Michel M.. 2011. Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506777
Modern Language Association (MLA)
Anose, Bynthia M.& Sanders, Michel M.. Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor. International Journal of Endocrinology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506777
American Medical Association (AMA)
Anose, Bynthia M.& Sanders, Michel M.. Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506777