Frequency of TGF-β and IFN-γ Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients

Joint Authors

Narciso, Roberto
Grabulosa, Caren Cristina
Dalboni, Maria Aparecida
Cendoroglo, Miguel
Rizzo, Luiz Vicente
Batista, Marcelo Costa
Quinto, Beata Marie Redublo
Durão, Marcelino
Monte, Julio Cesar
Santos, Oscar Fernando Pavão

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-07-23

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Medicine

Abstract EN

Genetic variations in TGF-β and IFN-γ may interfere with proinflammatory cytokine production and, consequently, may be involved with inflammatory diseases, as acute kidney injury (AKI).

We considered that genetic polymorphisms of these cytokines may have a crucial role in the outcome of critically ill patients.

To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-β, and rs2430561 (+874 T/A) from IFN-γ may be a risk factor for ICU patients to the development of AKI and/or death.

In a prospective nested case-control study, were included 139 ICU patients who developed AKI, 164 ICU patients without AKI, and 244 healthy individuals.

We observed a higher frequency to T/A genotype for IFN-γ (intermediate producer phenotype) and higher frequency of TT GG and TC GG genotype (high producer) for TGF-β polymorphism in overall population.

However, these polymorphisms have not been shown as a predictor of risk for AKI and death.

We found an increased prevalence of high and intermediate producer phenotypes from TGF-β and IFN-γ, respectively, in patients in ICU setting.

However, the studied genetic polymorphism of the TGF-β and IFN-γ was not associated as a risk factor for AKI or death in our population.

American Psychological Association (APA)

Grabulosa, Caren Cristina& Batista, Marcelo Costa& Cendoroglo, Miguel& Quinto, Beata Marie Redublo& Narciso, Roberto& Monte, Julio Cesar…[et al.]. 2014. Frequency of TGF-β and IFN-γ Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-506857

Modern Language Association (MLA)

Grabulosa, Caren Cristina…[et al.]. Frequency of TGF-β and IFN-γ Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-506857

American Medical Association (AMA)

Grabulosa, Caren Cristina& Batista, Marcelo Costa& Cendoroglo, Miguel& Quinto, Beata Marie Redublo& Narciso, Roberto& Monte, Julio Cesar…[et al.]. Frequency of TGF-β and IFN-γ Genotype as Risk Factors for Acute Kidney Injury and Death in Intensive Care Unit Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-506857

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-506857