Therapeutic Effects of the Superoxide Dismutase Mimetic Compound MnIIMe2DO2A on Experimental Articular Pain in Rats
Joint Authors
Valtancoli, Barbara
Failli, Paola
Ghelardini, Carla
Bani, Daniele
Calosi, Laura
Bencini, Andrea
Di Cesare Mannelli, Lorenzo
Cantore, Miriam
Brandi, Maria Luisa
Carossino, Anna Maria
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Superoxide anion (O2 •−) is overproduced in joint inflammation, rheumatoid arthritis, and osteoarthritis.
Increased O2 •− production leads to tissue damage, articular degeneration, and pain.
In these conditions, the physiological defense against O2 •−, superoxide dismutases (SOD) are decreased.
The MnII complex MnL4 is a potent SOD mimetic, and in this study it was tested in inflammatory and osteoarticular rat pain models.
In vivo protocols were approved by the animal Ethical Committee of the University of Florence.
Pain was measured by paw pressure and hind limb weight bearing alterations tests.
MnL4 (15 mg kg−1) acutely administered, significantly reduced pain induced by carrageenan, complete Freund’s adjuvant (CFA), and sodium monoiodoacetate (MIA).
In CFA and MIA protocols, it ameliorated the alteration of postural equilibrium.
When administered by osmotic pump in the MIA osteoarthritis, MnL4 reduced pain, articular derangement, plasma TNF alpha levels, and protein carbonylation.
The scaffold ring was ineffective.
MnL4 (10−7 M) prevented the lipid peroxidation of isolated human chondrocytes when O2 •− was produced by RAW 264.7.
MnL4 behaves as a potent pain reliever in acute inflammatory and chronic articular pain, being its efficacy related to antioxidant property.
Therefore MnL4 appears as a novel protective compound potentially suitable for the treatment of joint diseases.
American Psychological Association (APA)
Di Cesare Mannelli, Lorenzo& Bani, Daniele& Bencini, Andrea& Brandi, Maria Luisa& Calosi, Laura& Cantore, Miriam…[et al.]. 2013. Therapeutic Effects of the Superoxide Dismutase Mimetic Compound MnIIMe2DO2A on Experimental Articular Pain in Rats. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-506915
Modern Language Association (MLA)
Di Cesare Mannelli, Lorenzo…[et al.]. Therapeutic Effects of the Superoxide Dismutase Mimetic Compound MnIIMe2DO2A on Experimental Articular Pain in Rats. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-506915
American Medical Association (AMA)
Di Cesare Mannelli, Lorenzo& Bani, Daniele& Bencini, Andrea& Brandi, Maria Luisa& Calosi, Laura& Cantore, Miriam…[et al.]. Therapeutic Effects of the Superoxide Dismutase Mimetic Compound MnIIMe2DO2A on Experimental Articular Pain in Rats. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-506915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506915