Thrombospondin and VEGF-R : Is There a Correlation in Inflammatory Bowel Disease?

Joint Authors

Wejman, Jaroslaw
Tarnowski, Wieslaw
Szewczyk, Grzegorz
Jarosz, Dorota
Szukiewicz, Dariusz
Pyzlak, Michal

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-07-18

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases

Abstract EN

Up to date several authors discussed interactions between cells forming inflammatory infiltrates in the course of inflammatory bowel disease (IBD), mainly dealing with endoscopic biopsy specimens.

These usually contain only mucosa.

We have evaluated full bowel wall sections, which seems to be especially important in patients with Crohn's disease (CD).

The purpose of our study was to evaluate the relationship between vascular density and expression of thrombospondin-1 (TSP-1) and vascular endothelial growth factor receptor 1 (VEGFR-1) in full-thickness tissue fragments of intestinal wall taken from patients after colectomy, comparing those with IBD to non-IBD control group.

Histological sections were immunostained with antibodies against CD-31, TSP-1, and VEGFR-1 and analyzed by pathologists with the use of computer-assisted morphometrics.

Our research showed significantly higher vascular density and vascular area percentage in all layers of bowel wall in patients with CD when compared to control.

We have also demonstrated differences in vascular density distribution between ulcerative colitis (CU) and CD and between CU and control.

However we have not found statistically significant correlation between those findings and VEGFR-1 or TSP-1 expression.

Our results might suggest existence of different, TSP-1 independent pathways of antiangiogenesis in IBD.

American Psychological Association (APA)

Wejman, Jaroslaw& Pyzlak, Michal& Szukiewicz, Dariusz& Jarosz, Dorota& Tarnowski, Wieslaw& Szewczyk, Grzegorz. 2013. Thrombospondin and VEGF-R : Is There a Correlation in Inflammatory Bowel Disease?. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-507209

Modern Language Association (MLA)

Wejman, Jaroslaw…[et al.]. Thrombospondin and VEGF-R : Is There a Correlation in Inflammatory Bowel Disease?. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-507209

American Medical Association (AMA)

Wejman, Jaroslaw& Pyzlak, Michal& Szukiewicz, Dariusz& Jarosz, Dorota& Tarnowski, Wieslaw& Szewczyk, Grzegorz. Thrombospondin and VEGF-R : Is There a Correlation in Inflammatory Bowel Disease?. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-507209

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-507209