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Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity
Joint Authors
Mishra, Vinay
Bahekar, Rajesh
Ghumatkar, Priya
Jain, Mukul R.
Devada, Shilpesh
Sundar, Rajesh
Swain, Prabodha
Patel, Maulik V.
Ranvir, Ramchandra
Source
International Journal of Endocrinology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
T3 (3,5,3′-triiodothyronine) has drawn relatively little attention in relation to cardiovascular (CVS) diseases.
The present study was designed to evaluate the cardioprotective action of T3 in isoproterenol-(ISO-) induced cardiac toxicity.
Female Wistar rats were exposed with ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 h followed by T3 (3 μg/kg, body weight, orally) treatment for 3 days.
Positive control rats received only ISO (100 mg/kg, body weight, subcutaneously) for 2 days at the interval of 24 hrs.
Control group animals received normal saline as a vehicle.
As expected, ISO-induced significant changes were observed in low-density lipoprotein, total cholesterol, ALT, CK-MB to TCK ratio, and prolongation of QT interval in electrocardiogram, which is toward normalization after T3 treatment.
Lower heart weight, upregulation of cardiac myosin heavy chain alpha (MHC-α), and reduced inflammatory cell infiltration, myonecrosis, vacuolar changes, and a trend toward normal cardiac muscle fiber architecture in microscopic examination of cardiac tissue further support the cardioprotective effect of T3.
American Psychological Association (APA)
Mishra, Vinay& Ghumatkar, Priya& Patel, Maulik V.& Devada, Shilpesh& Ranvir, Ramchandra& Swain, Prabodha…[et al.]. 2011. Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity. International Journal of Endocrinology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507222
Modern Language Association (MLA)
Mishra, Vinay…[et al.]. Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity. International Journal of Endocrinology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-507222
American Medical Association (AMA)
Mishra, Vinay& Ghumatkar, Priya& Patel, Maulik V.& Devada, Shilpesh& Ranvir, Ramchandra& Swain, Prabodha…[et al.]. Evaluation of Cardioprotective Effect of 3,5,3′-Tri-iodo-L-thyronine in Isoproterenol-Induced Cardiotoxicity. International Journal of Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-507222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507222