The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer
Joint Authors
Shajahan, A. N.
Schwartz, J. L.
Clarke, Robert
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Resistance to endocrine therapy is common among breast cancer patients with estrogen receptor alpha-positive (ER+) tumors and limits the success of this therapeutic strategy.
While the mechanisms that regulate endocrine responsiveness and cell fate are not fully understood, interferon regulatory factor-1 (IRF1) is strongly implicated as a key regulatory node in the underlying signaling network.
IRF1 is a tumor suppressor that mediates cell fate by facilitating apoptosis and can do so with or without functional p53.
Expression of IRF1 is downregulated in endocrine-resistant breast cancer cells, protecting these cells from IRF1-induced inhibition of proliferation and/or induction of cell death.
Nonetheless, when IRF1 expression is induced following IFNγ treatment, antiestrogen sensitivity is restored by a process that includes the inhibition of prosurvival BCL2 family members and caspase activation.
These data suggest that a combination of endocrine therapy and compounds that effectively induce IRF1 expression may be useful for the treatment of many ER+ breast cancers.
By understanding IRF1 signaling in the context of endocrine responsiveness, we may be able to develop novel therapeutic strategies and better predict how patients will respond to endocrine therapy.
American Psychological Association (APA)
Schwartz, J. L.& Shajahan, A. N.& Clarke, Robert. 2011. The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507466
Modern Language Association (MLA)
Schwartz, J. L.…[et al.]. The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer. International Journal of Breast Cancer No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-507466
American Medical Association (AMA)
Schwartz, J. L.& Shajahan, A. N.& Clarke, Robert. The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507466