Aqp 9 and Brain Tumour Stem Cells
Joint Authors
Vik-Mo, Einar O.
Telmo, Emily
Kaarbø, Mari
Fossdal, Guri
Langmoen, Iver A.
Sandberg, Cecilie
Varghese, Mercy
Murrell, Wayne
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Several studies have implicated the aquaporins (aqp) 1, 4, and 9 in the pathogenesis of malignant brain tumours, suggesting that they contribute to motility, invasiveness, and oedema formation and facilitate metabolism in tumour cells under hypoxic conditions.
We have studied the expression of aqp1, 4, and 9 in biopsies from glioblastomas, isolated tumour stem cells grown in a tumoursphere assay and analyzed the progenitor and differentiated cells from these cultures.
We have compared these to the situation in normal rat brain, its stem cells, and differentiated cells derived thereof.
In short, qPCR in tumour tissue showed presence of aqp1, 4, and 9.
In the tumour progenitor population, aqp9 was markedly more highly expressed, whilst in tumour-derived differentiated cells, aqp4 was downregulated.
However, immunostaining did not reveal increased protein expression of aqp9 in the tumourspheres containing progenitor cells; in contrast, its expression (both mRNA and protein) was high in differentiated cultures.
We, therefore, propose that aquaporin 9 may have a central role in the tumorigenesis of glioblastoma.
American Psychological Association (APA)
Fossdal, Guri& Vik-Mo, Einar O.& Sandberg, Cecilie& Varghese, Mercy& Kaarbø, Mari& Telmo, Emily…[et al.]. 2012. Aqp 9 and Brain Tumour Stem Cells. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-507741
Modern Language Association (MLA)
Fossdal, Guri…[et al.]. Aqp 9 and Brain Tumour Stem Cells. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-507741
American Medical Association (AMA)
Fossdal, Guri& Vik-Mo, Einar O.& Sandberg, Cecilie& Varghese, Mercy& Kaarbø, Mari& Telmo, Emily…[et al.]. Aqp 9 and Brain Tumour Stem Cells. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-507741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507741