Combination of Infliximab and High-Dose Intravenous Immunoglobulin for Toxic Epidermal Necrolysis : Successful Treatment of an Elderly Patient
Joint Authors
Sidiras, Anastasios
Simelidis, Dimitrios
Solomonidis, Christos
Dolianitis, Konstantinos
Patmanidis, Konstantinos
Bassukas, Ioannis D.
Gaitanis, Georgios
Source
Case Reports in Dermatological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-09
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Toxic epidermal necrolysis (TEN) is a rare, severe cutaneous adverse drug reaction with average mortality 25–35%, especially among elderly multimorbid patients.
Established therapeutic guidelines do not exist and controversies underlie many of the presently suggested treatment regimens.
Herein we present the use of the recently described combination scheme of methylprednisolone (500 mg methylprednisolone bolus i.v.) followed by infliximab (5 mg/kg i.v.) and high-dose intravenous immunoglobulin (2 g/kg over 5 days) to treat an elderly, 74-year-old female patient with TEN (SCORTEN 3) within the premises of a district hospital.
Already from the second day of hospitalization the skin condition markedly stabilized and the patient's status improved rapidly thereafter.
She was discharged after 19 days in stationary care in excellent general condition and remained without any sequels 9 months afterwards.
The present paper further supports the feasibility, efficacy, and safety of the proposed combination modality for the treatment of elderly patients with TEN, a population susceptible to more severe TEN.
American Psychological Association (APA)
Patmanidis, Konstantinos& Sidiras, Anastasios& Dolianitis, Konstantinos& Simelidis, Dimitrios& Solomonidis, Christos& Gaitanis, Georgios…[et al.]. 2012. Combination of Infliximab and High-Dose Intravenous Immunoglobulin for Toxic Epidermal Necrolysis : Successful Treatment of an Elderly Patient. Case Reports in Dermatological Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-507763
Modern Language Association (MLA)
Patmanidis, Konstantinos…[et al.]. Combination of Infliximab and High-Dose Intravenous Immunoglobulin for Toxic Epidermal Necrolysis : Successful Treatment of an Elderly Patient. Case Reports in Dermatological Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-507763
American Medical Association (AMA)
Patmanidis, Konstantinos& Sidiras, Anastasios& Dolianitis, Konstantinos& Simelidis, Dimitrios& Solomonidis, Christos& Gaitanis, Georgios…[et al.]. Combination of Infliximab and High-Dose Intravenous Immunoglobulin for Toxic Epidermal Necrolysis : Successful Treatment of an Elderly Patient. Case Reports in Dermatological Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-507763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507763