Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Joint Authors
Ebina, Masahito
Miyasho, Taku
Nishimura, Hidekazu
Maruyama, Ikuro
Ohta, Hiromitsu
Hisata, Shu
Yamada, Shingo
Nukiwa, Toshihiro
Takashi, Kondo
Shibata, Naoko
Taniguchi, Hiroyuki
Ohkouchi, Shinya
Tamada, Tsutomu
Okada, Yoshinori
Ishizaka, Akitoshi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) remains to be elucidated.
To evaluate the roles of inflammatory mediators in acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), a chief mediator of acute lung injury, and 18 inflammatory cytokines were measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF patients after the onset of acute exacerbation.
HMGB1 gradually increased in the alveolar fluid after the onset of acute exacerbation, in positive correlation with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator.
In the lung tissues of eight IPF patients autopsied after acute exacerbation, intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial cells in alveolar capillary augmented lesions, where the capillary endothelial cells remarkably reduced the expression of thrombomodulin, an intrinsic antagonist of HMGB1.
These results suggest pathogenic roles for HMGB1 and MCP-1 in the late phase of acute exacerbation of IPF.
American Psychological Association (APA)
Ebina, Masahito& Taniguchi, Hiroyuki& Miyasho, Taku& Yamada, Shingo& Shibata, Naoko& Ohta, Hiromitsu…[et al.]. 2011. Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Pulmonary Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507862
Modern Language Association (MLA)
Ebina, Masahito…[et al.]. Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Pulmonary Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-507862
American Medical Association (AMA)
Ebina, Masahito& Taniguchi, Hiroyuki& Miyasho, Taku& Yamada, Shingo& Shibata, Naoko& Ohta, Hiromitsu…[et al.]. Gradual Increase of High Mobility Group Protein B1 in the Lungs after the Onset of Acute Exacerbation of Idiopathic Pulmonary Fibrosis. Pulmonary Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-507862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507862