PPAR-α Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice
Joint Authors
Esposito, Emanuela
Paterniti, Irene
Mazzon, Emanuela
Caminiti, Rocco
Dal Toso, Roberto
Cuzzocrea, Salvatore
Pressi, Giovanna
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The previous results suggest that peroxisome proliferator-activated receptor-alpha (PPAR)-α, an intracellular transcription factor activated by fatty acids, plays a role in control of inflammation.
There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity.
In this regard, it has been demonstrated that verbascoside (VB) functions as intracellular radical scavenger and reduces the microscopic and macroscopic signs of experimental colitis.
With the aim to characterize the role of PPAR-α in VB-mediated anti-inflammatory activity, we tested the efficacy of VB in an experimental model of inflammatory bowel disease induced by dinitrobenzene sulfonic acid, comparing mice lacking PPAR-α (PPAR-αKO) with wild type (WT) mice.
Results indicate that VB-mediated anti-inflammatory activity is weakened in PPAR-αKO mice, compared to WT controls, especially in the inhibition of neutrophil infiltration, intestinal permeability and colon injury.
These results indicate that PPAR-α can contribute to the anti-inflammatory activity of VB in inflammatory bowel disease.
American Psychological Association (APA)
Esposito, Emanuela& Mazzon, Emanuela& Paterniti, Irene& Dal Toso, Roberto& Pressi, Giovanna& Caminiti, Rocco…[et al.]. 2010. PPAR-α Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice. PPAR Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-507943
Modern Language Association (MLA)
Esposito, Emanuela…[et al.]. PPAR-α Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice. PPAR Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-507943
American Medical Association (AMA)
Esposito, Emanuela& Mazzon, Emanuela& Paterniti, Irene& Dal Toso, Roberto& Pressi, Giovanna& Caminiti, Rocco…[et al.]. PPAR-α Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-507943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507943