The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells
Joint Authors
Wise, Petra
Aleshcheva, Ganna
Pietsch, Jessica
Infanger, Manfred
Wehland, Markus
Ulbrich, Claudia
Grosse, Jirka
Grimm, Daniela
van Loon, Jack
Eilles, Christoph
Magnusson, Nils
Sundaresan, Alamelu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
How microgravity affects the biology of human cells and the formation of 3D cell cultures in real and simulated microgravity (r- and s-µg) is currently a hot topic in biomedicine.
In r- and s-µg, various cell types were found to form 3D structures.
This review will focus on the current knowledge of tissue engineering in space and on Earth using systems such as the random positioning machine (RPM), the 2D-clinostat, or the NASA-developed rotating wall vessel bioreactor (RWV) to create tissue from bone, tumor, and mesenchymal stem cells.
To understand the development of 3D structures, in vitro experiments using s-µg devices can provide valuable information about modulations in signal-transduction, cell adhesion, or extracellular matrix induced by altered gravity conditions.
These systems also facilitate the analysis of the impact of growth factors, hormones, or drugs on these tissue-like constructs.
Progress has been made in bone tissue engineering using the RWV, and multicellular tumor spheroids (MCTS), formed in both r- and s-µg, have been reported and were analyzed in depth.
Currently, these MCTS are available for drug testing and proteomic investigations.
This review provides an overview of the influence of µg on the aforementioned cells and an outlook for future perspectives in tissue engineering.
American Psychological Association (APA)
Ulbrich, Claudia& Wehland, Markus& Pietsch, Jessica& Aleshcheva, Ganna& Wise, Petra& van Loon, Jack…[et al.]. 2014. The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-508896
Modern Language Association (MLA)
Ulbrich, Claudia…[et al.]. The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-508896
American Medical Association (AMA)
Ulbrich, Claudia& Wehland, Markus& Pietsch, Jessica& Aleshcheva, Ganna& Wise, Petra& van Loon, Jack…[et al.]. The Impact of Simulated and Real Microgravity on Bone Cells and Mesenchymal Stem Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-508896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508896