Mannose-Binding Lectin Binds to Amyloid β Protein and Modulates Inflammation
Joint Authors
Elmaleh, David R.
Chang, Wei-Chuan
Takahashi, Kazue
Hartshorn, Kevan
Larvie, Mykol
Shoup, Timothy
Stahl, Gregory L.
Chigweshe, Lorencia
White, Mitchell R.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Mannose-binding lectin (MBL), a soluble factor of the innate immune system, is a pattern recognition molecule with a number of known ligands, including viruses, bacteria, and molecules from abnormal self tissues.
In addition to its role in immunity, MBL also functions in the maintenance of tissue homeostasis.
We present evidence here that MBL binds to amyloid β peptides.
MBL binding to other known carbohydrate ligands is calcium-dependent and has been attributed to the carbohydrate-recognition domain, a common feature of other C-type lectins.
In contrast, we find that the features of MBL binding to Aβ are more similar to the reported binding characteristics of the cysteine-rich domain of the unrelated mannose receptor and therefore may involve the MBL cysteine-rich domain.
Differences in MBL ligand binding may contribute to modulation of inflammatory response and may correlate with the function of MBL in processes such as coagulation and tissue homeostasis.
American Psychological Association (APA)
Larvie, Mykol& Shoup, Timothy& Chang, Wei-Chuan& Chigweshe, Lorencia& Hartshorn, Kevan& White, Mitchell R.…[et al.]. 2012. Mannose-Binding Lectin Binds to Amyloid β Protein and Modulates Inflammation. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509015
Modern Language Association (MLA)
Larvie, Mykol…[et al.]. Mannose-Binding Lectin Binds to Amyloid β Protein and Modulates Inflammation. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-509015
American Medical Association (AMA)
Larvie, Mykol& Shoup, Timothy& Chang, Wei-Chuan& Chigweshe, Lorencia& Hartshorn, Kevan& White, Mitchell R.…[et al.]. Mannose-Binding Lectin Binds to Amyloid β Protein and Modulates Inflammation. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-509015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509015