Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae
Joint Authors
Steen, Courtney M.
Boyer, Michael P.
Schaumberg, Jaron Z.
Schmidt, Martin
Source
International Journal of Microbiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
Boric acid (BA) has broad antimicrobial activity that makes it a popular treatment for yeast vaginitis in complementary and alternative medicine.
In the model yeast S.
cerevisiae, BA disturbs the cytoskeleton at the bud neck and impairs the assembly of the septation apparatus.
BA treatment causes cells to form irregular septa and leads to the synthesis of irregular cell wall protuberances that extend far into the cytoplasm.
The thick, chitin-rich septa that are formed during BA exposure prevent separation of cells after abscission and cause the formation of cell chains and clumps.
As a response to the BA insult, cells signal cell wall stress through the Slt2p pathway and increase chitin synthesis, presumably to repair cell wall damage.
American Psychological Association (APA)
Schmidt, Martin& Schaumberg, Jaron Z.& Steen, Courtney M.& Boyer, Michael P.. 2010. Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae. International Journal of Microbiology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-509070
Modern Language Association (MLA)
Schmidt, Martin…[et al.]. Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae. International Journal of Microbiology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-509070
American Medical Association (AMA)
Schmidt, Martin& Schaumberg, Jaron Z.& Steen, Courtney M.& Boyer, Michael P.. Boric Acid Disturbs Cell Wall Synthesis in Saccharomyces cerevisiae. International Journal of Microbiology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-509070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509070