Linking ER Stress to Autophagy : Potential Implications for Cancer Therapy
Joint Authors
Agostinis, Patrizia
Salazar, Maria
Verfaillie, Tom
Velasco, Guillermo
Source
International Journal of Cell Biology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-17
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Different physiological and pathological conditions can perturb protein folding in the endoplasmic reticulum, leading to a condition known as ER stress.
ER stress activates a complex intracellular signal transduction pathway, called unfolded protein response (UPR).
The UPR is tailored essentially to reestablish ER homeostasis also through adaptive mechanisms involving the stimulation of autophagy.
However, when persistent, ER stress can switch the cytoprotective functions of UPR and autophagy into cell death promoting mechanisms.
Recently, a variety of anticancer therapies have been linked to the induction of ER stress in cancer cells, suggesting that strategies devised to stimulate its prodeath function or block its prosurvival function, could be envisaged to improve their tumoricidial action.
A better understanding of the molecular mechanisms that determine the final outcome of UPR and autophagy activation by chemotherapeutic agents, will offer new opportunities to improve existing cancer therapies as well as unravel novel targets for cancer treatment.
American Psychological Association (APA)
Verfaillie, Tom& Salazar, Maria& Velasco, Guillermo& Agostinis, Patrizia. 2010. Linking ER Stress to Autophagy : Potential Implications for Cancer Therapy. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-509073
Modern Language Association (MLA)
Verfaillie, Tom…[et al.]. Linking ER Stress to Autophagy : Potential Implications for Cancer Therapy. International Journal of Cell Biology No. 2010 (2010), pp.1-19.
https://search.emarefa.net/detail/BIM-509073
American Medical Association (AMA)
Verfaillie, Tom& Salazar, Maria& Velasco, Guillermo& Agostinis, Patrizia. Linking ER Stress to Autophagy : Potential Implications for Cancer Therapy. International Journal of Cell Biology. 2010. Vol. 2010, no. 2010, pp.1-19.
https://search.emarefa.net/detail/BIM-509073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509073