GSK-3β : A Bifunctional Role in Cell Death Pathways
Joint Authors
Hallahan, Dennis E.
Bhave, Sandeep R.
Jaboin, Jerry J.
Ferraro, Daniel J.
Thotala, Dinesh
Jacobs, Keith M.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although glycogen synthase kinase-3 beta (GSK-3β) was originally named for its ability to phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional kinase is presently known to be a key regulator of a wide range of cellular functions.
GSK-3β is involved in modulating a variety of functions including cell signaling, growth metabolism, and various transcription factors that determine the survival or death of the organism.
Secondary to the role of GSK-3β in various diseases including Alzheimer’s disease, inflammation, diabetes, and cancer, small molecule inhibitors of GSK-3β are gaining significant attention.
This paper is primarily focused on addressing the bifunctional or conflicting roles of GSK-3β in both the promotion of cell survival and of apoptosis.
GSK-3β has emerged as an important molecular target for drug development.
American Psychological Association (APA)
Jacobs, Keith M.& Bhave, Sandeep R.& Ferraro, Daniel J.& Jaboin, Jerry J.& Hallahan, Dennis E.& Thotala, Dinesh. 2012. GSK-3β : A Bifunctional Role in Cell Death Pathways. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509091
Modern Language Association (MLA)
Jacobs, Keith M.…[et al.]. GSK-3β : A Bifunctional Role in Cell Death Pathways. International Journal of Cell Biology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-509091
American Medical Association (AMA)
Jacobs, Keith M.& Bhave, Sandeep R.& Ferraro, Daniel J.& Jaboin, Jerry J.& Hallahan, Dennis E.& Thotala, Dinesh. GSK-3β : A Bifunctional Role in Cell Death Pathways. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509091