Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice
Joint Authors
Kwon, Oh Sook
Yang, Beom Seok
Jung, Seung Hee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Manuka tree is indigenous to New Zealand, and its essential oil has been used as a traditional medicine to treat wounds, fever, and pain.
Although there is a growing interest in the use of manuka oil for antiaging skin care products, little is known about its bioactivity.
Solar ultraviolet (UV) radiation is the primary environmental factor causing skin damage and consequently premature aging.
Therefore, we evaluated manuka oil for its effects against photoaging in UV-B-irradiated hairless mice.
Topical application of manuka oil suppressed the UV-B-induced increase in skin thickness and wrinkle grading in a dose-dependent manner.
Application of 10% manuka oil reduced the average length, depth, and % area of wrinkles significantly, and this was correlated with inhibition of loss of collagen fiber content and epidermal hyperplasia.
Furthermore, we observed that manuka oil could suppress UV-B-induced skin inflammation by inhibiting the production of inflammatory cytokines.
Taken together, this study provides evidence that manuka oil indeed possesses antiphotoaging activity, and this is associated with its inhibitory activity against skin inflammation induced by UV irradiation.
American Psychological Association (APA)
Kwon, Oh Sook& Jung, Seung Hee& Yang, Beom Seok. 2013. Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509107
Modern Language Association (MLA)
Kwon, Oh Sook…[et al.]. Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-509107
American Medical Association (AMA)
Kwon, Oh Sook& Jung, Seung Hee& Yang, Beom Seok. Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509107