PPARγ, PTEN, and the Fight against Cancer
Joint Authors
Teresi, Rosemary E.
Waite, Kristin A.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor, which belongs to the family of nuclear hormone receptors.
Recent in vitro studies have shown that PPARγ can regulate the transcription of phosphatase and tensin homolog on chromosome ten (PTEN), a known tumor suppressor.
PTEN is a susceptibility gene for a number of disorders, including breast and thyroid cancer.
Activation of PPARγ through agonists increases functional PTEN protein levels that subsequently induces apoptosis and inhibits cellular growth, which suggests that PPARγ may be a tumor suppressor.
Indeed, several in vivo studies have demonstrated that genetic alterations of PPARγ can promote tumor progression.
These results are supported by observations of the beneficial effects of PPARγ agonists in the in vivo cancer setting.
These studies signify the importance of PPARγ and PTEN's interaction in cancer prevention.
American Psychological Association (APA)
Teresi, Rosemary E.& Waite, Kristin A.. 2008. PPARγ, PTEN, and the Fight against Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-509293
Modern Language Association (MLA)
Teresi, Rosemary E.& Waite, Kristin A.. PPARγ, PTEN, and the Fight against Cancer. PPAR Research No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-509293
American Medical Association (AMA)
Teresi, Rosemary E.& Waite, Kristin A.. PPARγ, PTEN, and the Fight against Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-509293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509293