Non-Alcoholic Fatty Liver Disease : The Bile Acid-Activated Farnesoid X Receptor as an Emerging Treatment Target
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Non-alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide.
It may progress to liver cirrhosis and liver cancer and is poised to represent the most common indication for liver transplantation in the near future.
The pathogenesis of NAFLD is multifactorial and not fully understood, but it represents an insulin resistance state characterized by a cluster of cardiovascular risk factors including obesity, dyslipidemia, hyperglycemia, and hypertension.
Importantly, NAFLD also has evolved as independent risk factor for cardiovascular disease.
Unfortunately thus far no established treatment does exist for NAFLD.
The bile acid-activated nuclear farnesoid X receptor (FXR) has been shown to play a role not only in bile acid but also in lipid and glucose homeostasis.
Specific targeting of FXR may be an elegant and very effective way to readjust dysregulated nuclear receptor-mediated metabolic pathways.
This review discusses the body's complex response to the activation of FXR with its beneficial actions but also potential undesirable side effects.
American Psychological Association (APA)
Fuchs, Michael. 2011. Non-Alcoholic Fatty Liver Disease : The Bile Acid-Activated Farnesoid X Receptor as an Emerging Treatment Target. Journal of Lipids،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-509377
Modern Language Association (MLA)
Fuchs, Michael. Non-Alcoholic Fatty Liver Disease : The Bile Acid-Activated Farnesoid X Receptor as an Emerging Treatment Target. Journal of Lipids No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-509377
American Medical Association (AMA)
Fuchs, Michael. Non-Alcoholic Fatty Liver Disease : The Bile Acid-Activated Farnesoid X Receptor as an Emerging Treatment Target. Journal of Lipids. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-509377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509377