Saussurea lappa Clarke-Derived Costunolide Prevents TNFα-Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF-κB Activity
Joint Authors
Woo, Sang-Mi
Ko, Seong-Gyu
Shin, Yong Cheol
Cho, Sung-Gook
Choi, Youn Kyung
Jo, Jeakyung
Yun, Yee Jin
Kim, Wooyoung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Saussurea lappa Clarke (SLC) has been used as a traditional medicine in Korea, China, and Japan for the treatment of abdominal pain and tenesmus.
Costunolide, a sesquiterpene lactone isolated from SLC, has diverse medicinal effects.
However, the anticancer effects of costunolide are still unclear in breast cancer.
In this study, we demonstrate that costunolide suppresses tumor growth and metastases of MDA-MB-231 highly metastatic human breast cancer cells via inhibiting TNFα-induced NF-κB activation.
Costunolide inhibited MDA-MB-231 tumor growth and metastases without affecting body weights in the in vivo mouse orthotopic tumor growth assays.
In addition, costunolide inhibited in vitro TNFα-induced invasion and migration of MDA-MB-231 cells.
Costunolide further suppressed TNFα-induced NF-κB signaling activation, resulting in a reduced expression of MMP-9, a well-known NF-κB-dependent gene to mediate breast cancer cell growth and metastases.
Therefore, we conclude that SLC and its derivative costunolide suppress breast cancer growth and metastases by inhibiting TNFα-induced NF-κB activation, suggesting that costunolide as well as SLC may be promising anticancer drugs, especially for metastatic breast cancer.
American Psychological Association (APA)
Choi, Youn Kyung& Cho, Sung-Gook& Woo, Sang-Mi& Yun, Yee Jin& Jo, Jeakyung& Kim, Wooyoung…[et al.]. 2013. Saussurea lappa Clarke-Derived Costunolide Prevents TNFα-Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF-κB Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509559
Modern Language Association (MLA)
Choi, Youn Kyung…[et al.]. Saussurea lappa Clarke-Derived Costunolide Prevents TNFα-Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF-κB Activity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-509559
American Medical Association (AMA)
Choi, Youn Kyung& Cho, Sung-Gook& Woo, Sang-Mi& Yun, Yee Jin& Jo, Jeakyung& Kim, Wooyoung…[et al.]. Saussurea lappa Clarke-Derived Costunolide Prevents TNFα-Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF-κB Activity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-509559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509559