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The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma
Joint Authors
Fujiwara, Hitoshi
Marunaka, Yoshinori
Otsuji, Eigo
Takemoto, Kenichi
Shiozaki, Atsushi
Komatsu, Shuhei
Konishi, Hirotaka
Kishimoto, Mitsuo
Ichikawa, Daisuke
Kosuga, Toshiyuki
Okamoto, Kazuma
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The objectives of the present study were to investigate the role of K–Cl cotransporter 3 (KCC3) in the regulation of cellular invasion and the clinicopathological significance of its expression in esophageal squamous cell carcinoma (ESCC).
Immunohistochemical analysis performed on 70 primary tumor samples obtained from ESCC patients showed that KCC3 was primarily found in the cytoplasm of carcinoma cells.
Although the expression of KCC3 in the main tumor (MT) was related to several clinicopathological features, such as the pT and pN categories, it had no prognostic impact.
KCC3 expression scores were compared between the MT and cancer nest (CN), and the survival rate of patients with a CN>MT score was lower than that of patients with a CN≤MT score.
In addition, the survival rate of patients in whom KCC3 was expressed in the invasive front of tumor was lower than that of the patients without it.
Furthermore, multivariate analysis demonstrated that the expression of KCC3 in the invasive front was one of the most important independent prognostic factors.
The depletion of KCC3 using siRNAs inhibited cell migration and invasion in human ESCC cell lines.
These results suggest that the expression of KCC3 in ESCC may affect cellular invasion and be related to a worse prognosis in patients with ESCC.
American Psychological Association (APA)
Shiozaki, Atsushi& Takemoto, Kenichi& Ichikawa, Daisuke& Fujiwara, Hitoshi& Konishi, Hirotaka& Kosuga, Toshiyuki…[et al.]. 2014. The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-509573
Modern Language Association (MLA)
Shiozaki, Atsushi…[et al.]. The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-509573
American Medical Association (AMA)
Shiozaki, Atsushi& Takemoto, Kenichi& Ichikawa, Daisuke& Fujiwara, Hitoshi& Konishi, Hirotaka& Kosuga, Toshiyuki…[et al.]. The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-509573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509573