ATP Release through Lysosomal Exocytosis from Peripheral Nerves : The Effect of Lysosomal Exocytosis on Peripheral Nerve Degeneration and Regeneration after Nerve Injury
Joint Authors
Kwon, Hyunseob
Jung, Junyang
Jo, Hyun Woo
Jeong, Na Young
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Studies have shown that lysosomal activation increases in Schwann cells after nerve injury.
Lysosomal activation is thought to promote the engulfment of myelin debris or fragments of injured axons in Schwann cells during Wallerian degeneration.
However, a recent interpretation of lysosomal activation proposes a different view of the phenomenon.
During Wallerian degeneration, lysosomes become secretory vesicles and are activated for lysosomal exocytosis.
The lysosomal exocytosis triggers adenosine 5′-triphosphate (ATP) release from peripheral neurons and Schwann cells during Wallerian degeneration.
Exocytosis is involved in demyelination and axonal degradation, which facilitate nerve regeneration following nerve degeneration.
At this time, released ATP may affect the communication between cells in peripheral nerves.
In this review, our description of the relationship between lysosomal exocytosis and Wallerian degeneration has implications for the understanding of peripheral nerve degenerative diseases and peripheral neuropathies, such as Charcot-Marie-Tooth disease or Guillain-Barré syndrome.
American Psychological Association (APA)
Jung, Junyang& Jo, Hyun Woo& Kwon, Hyunseob& Jeong, Na Young. 2014. ATP Release through Lysosomal Exocytosis from Peripheral Nerves : The Effect of Lysosomal Exocytosis on Peripheral Nerve Degeneration and Regeneration after Nerve Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509610
Modern Language Association (MLA)
Jung, Junyang…[et al.]. ATP Release through Lysosomal Exocytosis from Peripheral Nerves : The Effect of Lysosomal Exocytosis on Peripheral Nerve Degeneration and Regeneration after Nerve Injury. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-509610
American Medical Association (AMA)
Jung, Junyang& Jo, Hyun Woo& Kwon, Hyunseob& Jeong, Na Young. ATP Release through Lysosomal Exocytosis from Peripheral Nerves : The Effect of Lysosomal Exocytosis on Peripheral Nerve Degeneration and Regeneration after Nerve Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-509610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509610