Stress Degradation Studies on Flupirtine Maleate Using Stability-Indicating RP-HPLC Method
Joint Authors
Kathirvel, Singaram
Pandit, Mutukuri Risheela
Sujatha, Rachakonda
Suneetha, Achanti
Source
Chromatography Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
With the objective of developing an advanced method for rapid separation with shorter runtime, a simple, precise, and accurate stability-indicating isocratic RP-LC method coupled with PDA detector was developed for the quantitative determination of flupirtine maleate in bulk and in capsule dosage form.
Good resolution between the peaks for degradation products and the analyte was achieved on a Waters Agilent XDB C18 (150×4.6 mm, 5 μm) column using mobile phase containing a mixture of phosphate buffer pH 3.36 and acetonitrile in the ratio of 65 : 35.
The eluted compounds were monitored at 344 nm and the flow rate employed for the present investigation was 1 mL/min.
The newly developed method was validated as per ICH guidelines with respect to specificity, linearity, limit of detection, limit of quantification, accuracy, precision, and robustness.
The method may be employed for the assay determination of flupirtine maleate in pharmaceutical dosage forms.
American Psychological Association (APA)
Kathirvel, Singaram& Sujatha, Rachakonda& Pandit, Mutukuri Risheela& Suneetha, Achanti. 2013. Stress Degradation Studies on Flupirtine Maleate Using Stability-Indicating RP-HPLC Method. Chromatography Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-510009
Modern Language Association (MLA)
Kathirvel, Singaram…[et al.]. Stress Degradation Studies on Flupirtine Maleate Using Stability-Indicating RP-HPLC Method. Chromatography Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-510009
American Medical Association (AMA)
Kathirvel, Singaram& Sujatha, Rachakonda& Pandit, Mutukuri Risheela& Suneetha, Achanti. Stress Degradation Studies on Flupirtine Maleate Using Stability-Indicating RP-HPLC Method. Chromatography Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-510009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510009