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PPARγ and Agonists against Cancer : Rational Design of Complementation Treatments
Joint Authors
Volpert, Olga V.
Schulze-Hoëpfner, Frank Thilo
Veliceasa, Dorina
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARγ is a member of the ligand-activated nuclear receptor superfamily: its ligands act as insulin sensitizers and some are approved for the treatment of metabolic disorders in humans.
PPARγ has pleiotropic effects on survival and proliferation of multiple cell types, including cancer cells, and is now subject of intensive preclinical cancer research.
Studies of the recent decade highlighted PPARγ role as a potential modulator of angiogenesis in vitro and in vivo.
These observations provide an additional facet to the PPARγ image as potential anticancer drug.
Currently PPARγ is regarded as an important target for the therapies against angiogenesis-dependent pathological states including cancer and vascular complications of diabetes.
Some of the studies, however, identify pro-angiogenic and tumor-promoting effects of PPARγ and its ligands pointing out the need for further studies.
Below, we summarize current knowledge of PPARγ regulatory mechanisms and molecular targets, and discuss ways to maximize the beneficial activity of the PPARγ agonists.
American Psychological Association (APA)
Veliceasa, Dorina& Schulze-Hoëpfner, Frank Thilo& Volpert, Olga V.. 2008. PPARγ and Agonists against Cancer : Rational Design of Complementation Treatments. PPAR Research،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-510280
Modern Language Association (MLA)
Veliceasa, Dorina…[et al.]. PPARγ and Agonists against Cancer : Rational Design of Complementation Treatments. PPAR Research No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-510280
American Medical Association (AMA)
Veliceasa, Dorina& Schulze-Hoëpfner, Frank Thilo& Volpert, Olga V.. PPARγ and Agonists against Cancer : Rational Design of Complementation Treatments. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-510280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510280