Bone Effects of Biologic Drugs in Rheumatoid Arthritis
Joint Authors
Maruotti, Nicola
Cantatore, Francesco Paolo
Neve, Anna
Corrado, Addolorata
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Biologic agents used in the treatment of rheumatoid arthritis (RA) are able to reduce both disease activity and radiographic progression of joint disease.
These drugs are directed against several proinflammatory cytokines (TNFα, IL-6, and IL-1) which are involved both in the pathogenesis of chronic inflammation and progression of joint structural damage and in systemic and local bone loss typically observed in RA.
However, the role of biologic drugs in preventing bone loss in clinical practice has not yet clearly assessed.
Many clinical studies showed a trend to a positive effect of biologic agents in preventing systemic bone loss observed in RA.
Although the suppression of inflammation is the main goal in the treatment of RA and the anti-inflammatory effects of biologic drugs exert a positive effect on bone metabolism, the exact relationship between the prevention of bone loss and control of inflammation has not been clearly established, and if the available biologic drugs against TNFα, IL-1, and IL-6 can exert their effect on systemic and local bone loss also through a direct mechanism on bone cell metabolism is still to be clearly defined.
American Psychological Association (APA)
Corrado, Addolorata& Neve, Anna& Maruotti, Nicola& Cantatore, Francesco Paolo. 2013. Bone Effects of Biologic Drugs in Rheumatoid Arthritis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-510332
Modern Language Association (MLA)
Corrado, Addolorata…[et al.]. Bone Effects of Biologic Drugs in Rheumatoid Arthritis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-510332
American Medical Association (AMA)
Corrado, Addolorata& Neve, Anna& Maruotti, Nicola& Cantatore, Francesco Paolo. Bone Effects of Biologic Drugs in Rheumatoid Arthritis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-510332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510332