The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands : Having the Right Combination
Joint Authors
Skelhorne-Gross, Graham
Nicol, Christopher J. B.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success.
In spite of this, several groups reported exciting results with therapeutic regimens that combine PPARγ ligands with other compounds: chemotherapeutic agents, retinoid x receptor (RXR)α agonists, statins, or cell-to-cell signaling molecules in preclinical cancer models and human trials.
Here we have compiled an extensive review, consolidating the existing literature, which overwhelmingly supports a beneficial effect of treating with PPARγ ligands in combination with existing chemotherapies versus their monotherapy in cancer.
There are many examples in which combination therapy resulted in synergistic/additive effects on apoptosis, differentiation, and the ability to reduce cell growth and tumour burden.
There are also studies that indicate that PPARγ ligand pretreatment overcomes resistance and reduces toxicities.
Several mechanisms are explored to explain these protective effects.
This paper highlights each of these studies that, collectively, make a very strong case for the use of PPARγ ligands in combination with other agents in the treatment and management of several cancers.
American Psychological Association (APA)
Skelhorne-Gross, Graham& Nicol, Christopher J. B.. 2012. The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands : Having the Right Combination. PPAR Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-510428
Modern Language Association (MLA)
Skelhorne-Gross, Graham& Nicol, Christopher J. B.. The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands : Having the Right Combination. PPAR Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-510428
American Medical Association (AMA)
Skelhorne-Gross, Graham& Nicol, Christopher J. B.. The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands : Having the Right Combination. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-510428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510428