Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation
Joint Authors
Menétrey, Steeve
Peyter, Anne-Christine
Tolsa, Jean-François
Delhaes, Flavien
Diaceri, Giacomo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Adverse events in utero are associated with the occurrence of chronic diseases in adulthood.
We previously demonstrated in mice that perinatal hypoxia resulted in altered pulmonary circulation in adulthood, with a decreased endothelium-dependent relaxation of pulmonary arteries, associated with long-term alterations in the nitric oxide (NO)/cyclic GMP pathway.
The present study investigated whether inhaled NO (iNO) administered simultaneously to perinatal hypoxia could have potential beneficial effects on the adult pulmonary circulation.
Indeed, iNO is the therapy of choice in humans presenting neonatal pulmonary hypertension.
Long-term effects of neonatal iNO therapy on adult pulmonary circulation have not yet been investigated.
Pregnant mice were placed in hypoxia (13% O2) with simultaneous administration of iNO 5 days before delivery until 5 days after birth.
Pups were then raised in normoxia until adulthood.
Perinatal iNO administration completely restored acetylcholine-induced relaxation, as well as endothelial nitric oxide synthase protein content, in isolated pulmonary arteries of adult mice born in hypoxia.
Right ventricular hypertrophy observed in old mice born in hypoxia compared to controls was also prevented by perinatal iNO treatment.
Therefore, simultaneous administration of iNO during perinatal hypoxic exposure seems able to prevent adverse effects of perinatal hypoxia on the adult pulmonary circulation.
American Psychological Association (APA)
Peyter, Anne-Christine& Delhaes, Flavien& Diaceri, Giacomo& Menétrey, Steeve& Tolsa, Jean-François. 2014. Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510657
Modern Language Association (MLA)
Peyter, Anne-Christine…[et al.]. Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-510657
American Medical Association (AMA)
Peyter, Anne-Christine& Delhaes, Flavien& Diaceri, Giacomo& Menétrey, Steeve& Tolsa, Jean-François. Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-510657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510657