Generation of Chimeric “ABS Nanohemostat” Complex and Comparing Its Histomorphological In Vivo Effects to the Traditional Ankaferd Hemostat in Controlled Experimental Partial Nephrectomy Model
Joint Authors
Astarci, Müzeyyen
Toksoz, Sila
Dadali, Mumtaz
Haznedaroglu, Ibrahim C.
Guler, Mustafa O.
Beyazit, Yavuz
Ustun, Huseyin
Kekilli, Murat
Tekinay, Ayse B.
Huri, Emre
Celik, Tugrul
Mammadov, Rashad
Source
International Journal of Biomaterials
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Using the classical Ankaferd Blood Stopper (ABS) solution to create active hemostasis during partial nephrectomy (PN) may not be so effective due to insufficient contact surface between the ABS hemostatic liquid agent and the bleeding area.
In order to broaden the contact surface, we generated a chimeric hemostatic agent, ABS nanohemostat, via combining a self-assembling peptide amphiphile molecule with the traditional Ankaferd hemostat.
Materials and Methods.
In order to generate ABS nanohemostat, a positively charged Peptide Amphiphile (PA) molecule was synthesized by using solid phase peptide synthesis.
For animal experiments, 24 Wistar rats were divided into the following 4 groups: Group 1: control; Group 2: conventional PN with only 0.5 ml Ankaferd hemostat; Group 3: conventional PN with ABS + peptide gel; Group 4: conventional PN with only 0.5 ml peptide solution.
Results.
Mean warm ischemia times (WITs) were 232.8 ± 56.3, 65.6±11.4, 75.5± 17.2, and 58.1±17.6 seconds in Group 1 to Group 4, respectively.
Fibrosis was not different among the groups, while inflammation was detected to be significantly different in G3 and G4.
Conclusions.
ABS nanohemostat has comparable hemostatic efficacy to the traditional Ankaferd hemostat in the partial nephrectomy experimental model.
Elucidation of the cellular and tissue effects of this chimeric compound may establish a catalytic spark and open new avenues for novel experimental and clinical studies in the battlefield of hemostasis.
American Psychological Association (APA)
Huri, Emre& Beyazit, Yavuz& Mammadov, Rashad& Toksoz, Sila& Tekinay, Ayse B.& Guler, Mustafa O.…[et al.]. 2013. Generation of Chimeric “ABS Nanohemostat” Complex and Comparing Its Histomorphological In Vivo Effects to the Traditional Ankaferd Hemostat in Controlled Experimental Partial Nephrectomy Model. International Journal of Biomaterials،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510662
Modern Language Association (MLA)
Huri, Emre…[et al.]. Generation of Chimeric “ABS Nanohemostat” Complex and Comparing Its Histomorphological In Vivo Effects to the Traditional Ankaferd Hemostat in Controlled Experimental Partial Nephrectomy Model. International Journal of Biomaterials No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-510662
American Medical Association (AMA)
Huri, Emre& Beyazit, Yavuz& Mammadov, Rashad& Toksoz, Sila& Tekinay, Ayse B.& Guler, Mustafa O.…[et al.]. Generation of Chimeric “ABS Nanohemostat” Complex and Comparing Its Histomorphological In Vivo Effects to the Traditional Ankaferd Hemostat in Controlled Experimental Partial Nephrectomy Model. International Journal of Biomaterials. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-510662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510662