Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study
Joint Authors
Gearing, Marla
Scott, Tammy M.
Miller, L. Stephen
Hausman, Dorothy B.
Wittwer, Jonas
Vishwanathan, Rohini
Woodard, John L.
Green, Robert C.
Nelson, Peter T.
Davey, Adam
Johnson, Elizabeth J.
Johnson, Mary Ann
Poon, Leonard W.
Schalch, Wolfgang
Chung, Hae-Yun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Oxidative stress is involved in age-related cognitive decline.
The dietary antioxidants, carotenoids, tocopherols, and vitamin A may play a role in the prevention or delay in cognitive decline.
In this study, sera were obtained from 78 octogenarians and 220 centenarians from the Georgia Centenarian Study.
Brain tissues were obtained from 47 centenarian decedents.
Samples were analyzed for carotenoids, α-tocopherol, and retinol using HPLC.
Analyte concentrations were compared with cognitive tests designed to evaluate global cognition, dementia, depression and cognitive domains (memory, processing speed, attention, and executive functioning).
Serum lutein, zeaxanthin, and β-carotene concentrations were most consistently related to better cognition (P<0.05) in the whole population and in the centenarians.
Only serum lutein was significantly related to better cognition in the octogenarians.
In brain, lutein and β-carotene were related to cognition with lutein being consistently associated with a range of measures.
There were fewer significant relationships for α-tocopherol and a negative relationship between brain retinol concentrations and delayed recognition.
These findings suggest that the status of certain carotenoids in the old may reflect their cognitive function.
The protective effect may not be related to an antioxidant effect given that α-tocopherol was less related to cognition than these carotenoids.
American Psychological Association (APA)
Johnson, Elizabeth J.& Vishwanathan, Rohini& Johnson, Mary Ann& Hausman, Dorothy B.& Davey, Adam& Scott, Tammy M.…[et al.]. 2013. Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. Journal of Aging Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-510892
Modern Language Association (MLA)
Johnson, Elizabeth J.…[et al.]. Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. Journal of Aging Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-510892
American Medical Association (AMA)
Johnson, Elizabeth J.& Vishwanathan, Rohini& Johnson, Mary Ann& Hausman, Dorothy B.& Davey, Adam& Scott, Tammy M.…[et al.]. Relationship between Serum and Brain Carotenoids, α-Tocopherol, and Retinol Concentrations and Cognitive Performance in the Oldest Old from the Georgia Centenarian Study. Journal of Aging Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-510892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510892