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The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties
Joint Authors
Bellirou, Ahmed
Brown, Grant W.
Qaddouri, Bouchra
Bellaoui, Mohammed
Hamal, Abdellah
Melhaoui, Ahmed
Guaadaoui, Abdelkarim
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The budding yeast Saccharomyces cerevisiae is a valuable system to study cell-cycle regulation, which is defective in cancer cells.
Due to the highly conserved nature of the cell-cycle machinery between yeast and humans, yeast studies are directly relevant to anticancer-drug discovery.
The budding yeast is also an excellent model system for identifying and studying antifungal compounds because of the functional conservation of fungal genes.
Moreover, yeast studies have also contributed greatly to our understanding of the biological targets and modes of action of bioactive compounds.
Understanding the mechanism of action of clinically relevant compounds is essential for the design of improved second-generation molecules.
Here we describe our methodology for screening a library of plant-derived natural products in yeast in order to identify and characterize new compounds with anti-proliferative properties.
American Psychological Association (APA)
Qaddouri, Bouchra& Guaadaoui, Abdelkarim& Bellirou, Ahmed& Hamal, Abdellah& Melhaoui, Ahmed& Brown, Grant W.…[et al.]. 2011. The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-511128
Modern Language Association (MLA)
Qaddouri, Bouchra…[et al.]. The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-511128
American Medical Association (AMA)
Qaddouri, Bouchra& Guaadaoui, Abdelkarim& Bellirou, Ahmed& Hamal, Abdellah& Melhaoui, Ahmed& Brown, Grant W.…[et al.]. The Budding Yeast “Saccharomyces cerevisiae” as a Drug Discovery Tool to Identify Plant-Derived Natural Products with Anti-Proliferative Properties. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-511128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511128