Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons
Joint Authors
Jang, Il-Sung
Nakamura, Michiko
Choi, Kwi-Hyung
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The periaqueductal gray (PAG) is involved in the central regulation of nociceptive transmission by affecting the descending inhibitory pathway.
In the present study, we have addressed the functional role of presynaptic glycine receptors in spontaneous glutamatergic transmission.
Spontaneous EPSCs (sEPSCs) were recorded in mechanically dissociated rat PAG neurons using a conventional whole-cell patch recording technique under voltage-clamp conditions.
The application of glycine (100 µM) significantly increased the frequency of sEPSCs, without affecting the amplitude of sEPSCs.
The glycine-induced increase in sEPSC frequency was blocked by 1 µM strychnine, a specific glycine receptor antagonist.
The results suggest that glycine acts on presynaptic glycine receptors to increase the probability of glutamate release from excitatory nerve terminals.
The glycine-induced increase in sEPSC frequency completely disappeared either in the presence of tetrodotoxin or Cd2+, voltage-gated Na+, or Ca2+ channel blockers, suggesting that the activation of presynaptic glycine receptors might depolarize excitatory nerve terminals.
The present results suggest that presynaptic glycine receptors can regulate the excitability of PAG neurons by enhancing glutamatergic transmission and therefore play an important role in the regulation of various physiological functions mediated by the PAG.
American Psychological Association (APA)
Choi, Kwi-Hyung& Nakamura, Michiko& Jang, Il-Sung. 2013. Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons. Neural Plasticity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-511150
Modern Language Association (MLA)
Choi, Kwi-Hyung…[et al.]. Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons. Neural Plasticity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-511150
American Medical Association (AMA)
Choi, Kwi-Hyung& Nakamura, Michiko& Jang, Il-Sung. Presynaptic Glycine Receptors Increase GABAergic Neurotransmission in Rat Periaqueductal Gray Neurons. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-511150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511150