The −174GC and −572GC Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis : A Case-Control Study
Joint Authors
Martín-Márquez, Beatriz Teresita
Díaz-Toscano, Miriam Lizette
Ponce-Guarneros, Manuel
Martínez-García, Erika Aurora
Zavaleta-Muñiz, Soraya Amali
Gonzalez-Lopez, Laura
Vázquez-Del Mercado, Mónica
Fafutis-Morris, M.
Gamez-Nava, Jorge Ivan
Flores-Martínez, S. E.
Maldonado-González, M.
Gonzalez-Montoya, N. G.
Ruiz-Padilla, A. J.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
There is a lack of information about the genotype frequencies of IL-6 −174G/C and −572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA).
Therefore, the aim of this study was to evaluate the association of the IL-6 −174G/C and −572G/C polymorphisms in Mexican mestizo with RA.
Methods.
We included 137 patients with RA and 102 healthy controls.
Patients were assessed for clinical characteristics.
IL-6 −174G/C and −572G/C polymorphisms were genotyped using PCR-RFLP analysis.
Allele and genotype frequencies and the Hardy-Weinberg equilibrium were computed.
Odds ratios (ORs) were computed to identify the risk for RA associated with the presence of GG genotype in comparison with the GC or CC genotypes.
Results.
The genotype −174GG occurred at a higher frequency in cases and controls (77.4% versus 78.4%, P=0.845).
We found similar results for the genotype −572GG (54% in patients versus 60.8% in controls, P=0.295).
Conclusions.
This is the first study to evaluate the association of −174G/C and −572G/C polymorphisms of the IL-6 gene with RA in Mexican mestizo patients.
These two polymorphisms were not associated with RA in the studied sample.
Additional studies are required to evaluate if these IL-6 polymorphisms have relevance to the development of more severe disease.
American Psychological Association (APA)
Zavaleta-Muñiz, Soraya Amali& Martín-Márquez, Beatriz Teresita& Gonzalez-Lopez, Laura& Gonzalez-Montoya, N. G.& Díaz-Toscano, Miriam Lizette& Ponce-Guarneros, Manuel…[et al.]. 2013. The −174GC and −572GC Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis : A Case-Control Study. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-511490
Modern Language Association (MLA)
Zavaleta-Muñiz, Soraya Amali…[et al.]. The −174GC and −572GC Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis : A Case-Control Study. Clinical and Developmental Immunology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-511490
American Medical Association (AMA)
Zavaleta-Muñiz, Soraya Amali& Martín-Márquez, Beatriz Teresita& Gonzalez-Lopez, Laura& Gonzalez-Montoya, N. G.& Díaz-Toscano, Miriam Lizette& Ponce-Guarneros, Manuel…[et al.]. The −174GC and −572GC Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis : A Case-Control Study. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-511490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511490