CSF Biomarkers Profile in CADASIL—A Model of Pure Vascular Dementia : Usefulness in Differential Diagnosis in the Dementia Disorder
Joint Authors
Formichi, Patrizia
Dotti, Maria Teresa
Parnetti, Lucilla
Radi, Elena
Federico, Antonio
Cevenini, Gabriele
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is considered a model of pure vascular dementia (VD) because it occurs in young adults unlikely to have concomitant age and Alzheimer's Disease-(AD-) related pathology.
CSF levels of β-amyloid 1-42 (Aβ42), total tau protein (t-tau), and phosphorylated tau-protein (p-tau), well accepted biomarkers of AD, were evaluated in 10 CADASIL patients, 22 AD patients, and 17 healthy age-matched subjects.
Innotest β-amyloid 1-42, Innotest hTAU-Ag, and Innotest Phospho-tau 181p sandwich enzyme-linked immunoassay were used to determine CSF biomarkers levels.
A case-control statistical analysis was carried out.
CSF Aβ42 levels were significantly lower in CADASIL patients and considerable overlap with AD whereas t-tau and p-tau levels were normal and significantly different with respect to AD.
A significant altered CSF biomarkers profile in a pure VD supports the use of CSF Aβ42, t-tau, and p-tau levels in the differential diagnosis of VD and AD.
American Psychological Association (APA)
Formichi, Patrizia& Parnetti, Lucilla& Radi, Elena& Cevenini, Gabriele& Dotti, Maria Teresa& Federico, Antonio. 2010. CSF Biomarkers Profile in CADASIL—A Model of Pure Vascular Dementia : Usefulness in Differential Diagnosis in the Dementia Disorder. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511506
Modern Language Association (MLA)
Formichi, Patrizia…[et al.]. CSF Biomarkers Profile in CADASIL—A Model of Pure Vascular Dementia : Usefulness in Differential Diagnosis in the Dementia Disorder. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-511506
American Medical Association (AMA)
Formichi, Patrizia& Parnetti, Lucilla& Radi, Elena& Cevenini, Gabriele& Dotti, Maria Teresa& Federico, Antonio. CSF Biomarkers Profile in CADASIL—A Model of Pure Vascular Dementia : Usefulness in Differential Diagnosis in the Dementia Disorder. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-511506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511506