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Molecular Characterization and Expression of α-Globin and β-Globin Genes in the Euryhaline Flounder (Platichthys flesus)
Joint Authors
Luo, Lei
Balment, Richard J.
Cui, Guoqiang
Lu, Weiqun
Mayolle, Aurelie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In order to understand the possible role of globin genes in fish salinity adaptation, we report the molecular characterization and expression of all four subunits of haemoglobin, and their response to salinity challenge in flounder.
The entire open reading frames of α1-globin and α2-globin genes were 432 and 435 bp long, respectively, whereas the β1-globin and β2-globin genes were both 447 bp.
Although the head kidney (pronephros) is the predicted major site of haematopoiesis, real-time PCR revealed that expression of α-globin and β-globin in kidney (mesonephros) was 1.5 times higher than in head kidney.
Notably, the α1-globin and β1-globin mRNA expression was higher than α2-globin and β2-globin in kidney.
Expression levels of all four globin subunits were higher in freshwater- (FW-) than in seawater- (SW-)adapted fish kidney.
If globins do play a role in salinity adaptation, this is likely to be more important in combating the hemodilution faced by fish in FW than the dehydration and salt loading which occur in SW.
American Psychological Association (APA)
Lu, Weiqun& Mayolle, Aurelie& Cui, Guoqiang& Luo, Lei& Balment, Richard J.. 2011. Molecular Characterization and Expression of α-Globin and β-Globin Genes in the Euryhaline Flounder (Platichthys flesus). Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-512014
Modern Language Association (MLA)
Lu, Weiqun…[et al.]. Molecular Characterization and Expression of α-Globin and β-Globin Genes in the Euryhaline Flounder (Platichthys flesus). Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-512014
American Medical Association (AMA)
Lu, Weiqun& Mayolle, Aurelie& Cui, Guoqiang& Luo, Lei& Balment, Richard J.. Molecular Characterization and Expression of α-Globin and β-Globin Genes in the Euryhaline Flounder (Platichthys flesus). Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-512014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512014