Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury
Joint Authors
Zhang, Zheng
Li, Qiang
Peng, Yu
Bai, Ming
Zhang, Lu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor α is a member of the nuclear receptor superfamily.
It modulates smooth muscle cell proliferation and inflammatory cytokines in vitro.
In this study, we tested the hypothesis that PPARα would decrease the expression of monocyte chemoattractant protein-1 and tissue factor, and inhibit neointimal formation in a murine double carotid artery injury model.
Carotid artery injury was performed in the PPARα knockout and wild type (WT) mice, treated and untreated with Wy14643, a PPARα activator.
Up-regulated MCP-1 and TF expression and more neointimal formation were observed in the PPARα−/− mice compared with WT mice.
The activation of PPARα resulted in further decreased neointimal formation.
Our data further suggest that the decrease in neointimal formation is due to down-regulation of MCP-1 by PPARα resulting in decreased leukocyte infiltration and TF expression.
American Psychological Association (APA)
Peng, Yu& Li, Qiang& Zhang, Lu& Bai, Ming& Zhang, Zheng. 2012. Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury. PPAR Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-512361
Modern Language Association (MLA)
Peng, Yu…[et al.]. Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury. PPAR Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-512361
American Medical Association (AMA)
Peng, Yu& Li, Qiang& Zhang, Lu& Bai, Ming& Zhang, Zheng. Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-512361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512361