Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance

Joint Authors

Jackson, Claire
Tyson-Capper, Alison
Browell, David
Gautrey, Hannah

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-07-01

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Biology

Abstract EN

Overexpression of human epidermal growth factor receptor (HER-2) occurs in 20–30% of breast cancers and confers survival and proliferative advantages on the tumour cells making HER-2 an ideal therapeutic target for drugs like Herceptin.

Continued delineation of tumour biology has identified splice variants of HER-2, with contrasting roles in tumour cell biology.

For example, the splice variant Δ16HER-2 (results from exon 16 skipping) increases transformation of cancer cells and is associated with treatment resistance; conversely, Herstatin (results from intron 8 retention) and p100 (results from intron 15 retention) inhibit tumour cell proliferation.

This review focuses on the potential clinical implications of the expression and coexistence of HER-2 splice variants in cancer cells in relation to breast cancer progression and drug resistance.

“Individualised” strategies currently guide breast cancer management; in accordance, HER-2 splice variants may prove valuable as future prognostic and predictive factors, as well as potential therapeutic targets.

American Psychological Association (APA)

Jackson, Claire& Browell, David& Gautrey, Hannah& Tyson-Capper, Alison. 2013. Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512670

Modern Language Association (MLA)

Jackson, Claire…[et al.]. Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance. International Journal of Cell Biology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-512670

American Medical Association (AMA)

Jackson, Claire& Browell, David& Gautrey, Hannah& Tyson-Capper, Alison. Clinical Significance of HER-2 Splice Variants in Breast Cancer Progression and Drug Resistance. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-512670

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-512670