Interaction of Botulinum Toxin with the Epithelial Barrier
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Botulinum neurotoxin (BoNT) is a protein toxin (~150 kDa), which possesses a metalloprotease activity.
Food-borne botulism is manifested when BoNT is absorbed from the digestive tract to the blood stream and enters the peripheral nerves, where the toxin cleaves core proteins of the neuroexocytosis apparatus and elicits the inhibition of neurotransmitter release.
The initial obstacle to orally ingested BoNT entering the body is the epithelial barrier of the digestive tract.
Recent cell biology and molecular biology studies are beginning to elucidate the mechanism by which this large protein toxin crosses the epithelial barrier.
In this review, we provide an overview of the structural features of botulinum toxins (BoNT and BoNT complex) and the interaction of these toxins with the epithelial barrier.
American Psychological Association (APA)
Fujinaga, Yukako. 2010. Interaction of Botulinum Toxin with the Epithelial Barrier. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-512806
Modern Language Association (MLA)
Fujinaga, Yukako. Interaction of Botulinum Toxin with the Epithelial Barrier. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-512806
American Medical Association (AMA)
Fujinaga, Yukako. Interaction of Botulinum Toxin with the Epithelial Barrier. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-512806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512806
