PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling
Joint Authors
Ehara, Takashi
Kamijo, Yuji
Nakajima, Takero
Aoyama, Toshifumi
Hashimoto, Koji
Higuchi, Makoto
Harada, Makoto
Shigematsu, Hidekazu
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The vast increase of chronic kidney disease (CKD) has attracted considerable attention worldwide, and the development of a novel therapeutic option against a representative kidney disease that leads to CKD, mesangial proliferative glomerulonephritis (MsPGN) would be significant.
Peroxisome proliferator-activated receptor α (PPARα), a member of the steroid/nuclear receptor superfamily, is known to perform various physiological functions.
Recently, we reported that PPARα in activated mesangial cells exerted anti-inflammatory effects and that the deficiency of PPARα resulted in high susceptibility to glomerulonephritis.
To investigate whether PPARα activation improves the disease activity of MsPGN, we examined the protective effects of a PPARα agonist, clofibrate, in a well-established model of human MsPGN, anti-Thy1 nephritis, for the first time.
This study demonstrated that pretreatment with clofibrate (via a 0.02% or 0.1% clofibrate-containing diet) continuously activated the glomerular PPARα, which outweighed the PPARα deterioration associated with the nephritic process.
The PPARα activation appeared to suppress the NF-κB signaling pathway in glomeruli by the induction of IκBα, resulting in the reduction of proteinuria and the amelioration of the active inflammatory pathologic glomerular changes.
These findings suggest the antinephritic potential of PPARα-related medicines against MsPGN.
PPARα-related medicines might be useful as a treatment option for CKD.
American Psychological Association (APA)
Hashimoto, Koji& Kamijo, Yuji& Nakajima, Takero& Harada, Makoto& Higuchi, Makoto& Ehara, Takashi…[et al.]. 2012. PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling. PPAR Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512904
Modern Language Association (MLA)
Hashimoto, Koji…[et al.]. PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling. PPAR Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-512904
American Medical Association (AMA)
Hashimoto, Koji& Kamijo, Yuji& Nakajima, Takero& Harada, Makoto& Higuchi, Makoto& Ehara, Takashi…[et al.]. PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-512904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512904