Idealized PPARγ-Based Therapies : Lessons from Bench and Bedside
Joint Authors
de Assis Rocha Neves, Francisco
Amato, Angélica Amorim
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The incidence of type 2 (T2D) diabetes and other chronic conditions associated with insulin resistance is increasing at an alarming rate, underscoring the need for effective and safe therapeutic strategies.
Peroxisome-proliferator-activated receptor gamma (PPARγ) has emerged as a critical regulator of glucose homeostasis, lipid homeostasis, and vascular inflammation.
Currently marketed drugs targeting this receptor, the thiazolidinediones (TZDs), have proven benefits on insulin resistance and hyperglycemia associated with T2D.
Unfortunately, they have been associated with long-term unfavorable effects on health, such as weight gain, plasma volume expansion, bone loss, cardiovascular toxicity, and possibly cancer, and these safety concerns have led to reduced interest for many PPARγ ligands.
However, over the last years, data from human genetic studies, animal models, and studies with ligands have increased our understanding of PPARγ’s actions and provided important insights into how ligand development strategies could be optimized to increase effectiveness and safety of PPARγ-based therapies.
American Psychological Association (APA)
Amato, Angélica Amorim& de Assis Rocha Neves, Francisco. 2012. Idealized PPARγ-Based Therapies : Lessons from Bench and Bedside. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513070
Modern Language Association (MLA)
Amato, Angélica Amorim& de Assis Rocha Neves, Francisco. Idealized PPARγ-Based Therapies : Lessons from Bench and Bedside. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513070
American Medical Association (AMA)
Amato, Angélica Amorim& de Assis Rocha Neves, Francisco. Idealized PPARγ-Based Therapies : Lessons from Bench and Bedside. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513070