Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures
Joint Authors
Merlino, Francesco
Grieco, Paolo
Munaim Yousif, Ali
Di Maro, Salvatore
Caraglia, Michele
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Urotensin-II was originally isolated from the goby urophysis in the 1960s as a vasoactive peptide with a prominent role in cardiovascular homeostasis.
The identification of human isoform of urotensin-II and its specific UT receptor by Ames et al.
in 1999 led to investigating the putative role of the interaction U-II/UT receptor in multiple pathophysiological effects in humans.
Since urotensin-II is widely expressed in several peripheral tissues including cardiovascular system, the design and development of novel urotensin-II analogues can improve knowledge about structure-activity relationships (SAR).
In particular, since the modulation of the U-II system offers a great potential for therapeutic strategies related to the treatment of several diseases, like cardiovascular diseases, the research of selective and potent ligands at UT receptor is more fascinating.
In this paper, we review the developments of peptide and nonpeptide U-II structures so far developed in order to contribute also to a more rational and detectable design and synthesis of new molecules with high affinity at the UT receptor.
American Psychological Association (APA)
Merlino, Francesco& Di Maro, Salvatore& Munaim Yousif, Ali& Caraglia, Michele& Grieco, Paolo. 2013. Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures. Journal of Amino Acids،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-513095
Modern Language Association (MLA)
Merlino, Francesco…[et al.]. Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures. Journal of Amino Acids No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-513095
American Medical Association (AMA)
Merlino, Francesco& Di Maro, Salvatore& Munaim Yousif, Ali& Caraglia, Michele& Grieco, Paolo. Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures. Journal of Amino Acids. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-513095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513095