Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures

Joint Authors

Merlino, Francesco
Grieco, Paolo
Munaim Yousif, Ali
Di Maro, Salvatore
Caraglia, Michele

Source

Journal of Amino Acids

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-02-25

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Chemistry

Abstract EN

Urotensin-II was originally isolated from the goby urophysis in the 1960s as a vasoactive peptide with a prominent role in cardiovascular homeostasis.

The identification of human isoform of urotensin-II and its specific UT receptor by Ames et al.

in 1999 led to investigating the putative role of the interaction U-II/UT receptor in multiple pathophysiological effects in humans.

Since urotensin-II is widely expressed in several peripheral tissues including cardiovascular system, the design and development of novel urotensin-II analogues can improve knowledge about structure-activity relationships (SAR).

In particular, since the modulation of the U-II system offers a great potential for therapeutic strategies related to the treatment of several diseases, like cardiovascular diseases, the research of selective and potent ligands at UT receptor is more fascinating.

In this paper, we review the developments of peptide and nonpeptide U-II structures so far developed in order to contribute also to a more rational and detectable design and synthesis of new molecules with high affinity at the UT receptor.

American Psychological Association (APA)

Merlino, Francesco& Di Maro, Salvatore& Munaim Yousif, Ali& Caraglia, Michele& Grieco, Paolo. 2013. Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures. Journal of Amino Acids،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-513095

Modern Language Association (MLA)

Merlino, Francesco…[et al.]. Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures. Journal of Amino Acids No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-513095

American Medical Association (AMA)

Merlino, Francesco& Di Maro, Salvatore& Munaim Yousif, Ali& Caraglia, Michele& Grieco, Paolo. Urotensin-II Ligands : An Overview from Peptide to Nonpeptide Structures. Journal of Amino Acids. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-513095

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-513095