Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions
Joint Authors
Li, Jia
Wan, Qin
Li, Xia
Chen, Guo
Xu, Yong
Liu, Li
Gao, Chenlin
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The involvement of the Notch signaling pathway in the cellular differentiation of the mammalian kidney is established.
Recently, the dysregulation of Notch signaling molecules has been identified in acute and chronic renal injuries, fibrosis models, and diabetic kidney biopsies.
The canonical Notch ligand , Jagged1, is upregulated in a transforming growth factor-beta- (TGF-β-) dependent manner during chronic kidney disease.
TGF-β, a central mediator of renal fibrosis, also is a major contributor to the development of diabetic nephropathy.
To explore the roles and possible mechanisms of Notch signaling molecules in the pathogenesis of diabetic nephropathy, we exposed cultured rat mesangial cells to a γ-secretase inhibitor (DAPT) or high glucose and measured the expression of Notch signaling molecules and the fibrosis index.
Notch pathway-related molecules, TGF-β, and fibronectin increased with exposure to high glucose and decreased with DAPT treatment.
Our results suggest that the Notch signaling pathway may precipitate diabetic nephropathy via TGF-β activation.
American Psychological Association (APA)
Liu, Li& Gao, Chenlin& Chen, Guo& Li, Xia& Li, Jia& Wan, Qin…[et al.]. 2013. Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513142
Modern Language Association (MLA)
Liu, Li…[et al.]. Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-513142
American Medical Association (AMA)
Liu, Li& Gao, Chenlin& Chen, Guo& Li, Xia& Li, Jia& Wan, Qin…[et al.]. Notch Signaling Molecules Activate TGF-β in Rat Mesangial Cells under High Glucose Conditions. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-513142
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513142