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Integrated Genomic Analysis of Sézary Syndrome
Joint Authors
Mao, Xin
Chaplin, Tracy
Young, Bryan D.
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sézary syndrome (SS) is a rare variant of primary cutaneous T-cell lymphoma.
Little is known about the underlying pathogenesis of S.
To address this issue, we used Affymetrix 10K SNP microarray to analyse 13 DNA samples isolated from 8 SS patients and qPCR with ABI TaqMan SNP genotyping assays for the validation of the SNP microarray results.
In addition, we tested the impact of SNP loss of heterozygosity (LOH) identified in SS cases on the gene expression profiles of SS cases detected with Affymetrix GeneChip U133A.
The results showed: (1) frequent SNP copy number change and LOH involving 1, 2p, 3, 4q, 5q, 6, 7p, 8, 9, 10, 11, 12q, 13, 14, 16q, 17, and 20, (2) reduced SNP copy number at FAT gene (4q35) in 75% of SS cases, and (3) the separation of all SS cases from normal control samples by SNP LOH gene clusters at chromosome regions of 9q31q34, 10p11q26, and 13q11q12.
These findings provide some intriguing information for our current understanding of the molecular pathogenesis of this tumour and suggest the possibility of presence of functional SNP LOH in SS tumour cells.
American Psychological Association (APA)
Mao, Xin& Chaplin, Tracy& Young, Bryan D.. 2011. Integrated Genomic Analysis of Sézary Syndrome. Genetics Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-513164
Modern Language Association (MLA)
Mao, Xin…[et al.]. Integrated Genomic Analysis of Sézary Syndrome. Genetics Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-513164
American Medical Association (AMA)
Mao, Xin& Chaplin, Tracy& Young, Bryan D.. Integrated Genomic Analysis of Sézary Syndrome. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-513164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513164