Enhanced Hemostatic Performance of Tranexamic Acid-Loaded ChitosanAlginate Composite Microparticles
Joint Authors
Liu, Jiancang
Zang, Jiatao
Li, Donghong
Li, Pengxi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Novel microparticles based on chitosan and sodium alginate were prepared using emulsification and cross-linking technologies.
The spherical microparticles had a porous surface and a diameter of 2~40 μm.
In simulated body fluid, these microparticles quickly swelled but gradually degraded.
The results of the MTT assay revealed that a slight inhibition of cell proliferation was observed on day 2 and then gradually decreased afterward.
No cell morphology changes were observed.
By loading tranexamic acid, the hemostatic performance of the microparticles was obviously improved.
Using fast-acting styptic powder (Flashclot) as the control, the hemostatic efficiency was investigated in rabbits using a liver transection bleeding model.
It was found that both Flashclot and the microparticles achieved hemostasis in 3.07±0.84 min and 2.48±0.88 min, respectively; however, the tranexamic acid-loaded microparticles stopped the bleeding in 1.90±0.75 min (P<0.05).
Additionally, Flashclot resulted in heat injury to the experimental livers, while the microparticles did not.
Thus, with their biodegradability, safety, and superior hemostatic efficiency, tranexamic acid-loaded microparticles might be a promising new powdered hemostatic agent with a wide range of potential applications.
American Psychological Association (APA)
Li, Donghong& Li, Pengxi& Zang, Jiatao& Liu, Jiancang. 2012. Enhanced Hemostatic Performance of Tranexamic Acid-Loaded ChitosanAlginate Composite Microparticles. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513287
Modern Language Association (MLA)
Li, Donghong…[et al.]. Enhanced Hemostatic Performance of Tranexamic Acid-Loaded ChitosanAlginate Composite Microparticles. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-513287
American Medical Association (AMA)
Li, Donghong& Li, Pengxi& Zang, Jiatao& Liu, Jiancang. Enhanced Hemostatic Performance of Tranexamic Acid-Loaded ChitosanAlginate Composite Microparticles. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-513287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513287